SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES

Bis-alkylquinolines 1-6 were synthetized via Williamson reaction between 8-hydroxyquinaldine with different É, ù-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Cytotoxic and antileishmanial activities of synthesized compounds were determinated on U-937 cells and L. (V) panamensis amastigotes, respectively. Compound 5, 1,9-bis[(2-methylquinolin-8-yl)oxy]nonane, was the most selective against axenic and intracellular amastigotes (EC50 = 11.3 and 22.6, ìg/mL), with selectivity indices greater than 17.7 and 8.8, respectively; which makes this compound promising for the developing of new leishmanicidal drugs.

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Bibliographic Details
Main Authors: CARDONA,WILSON, ARANGO,VICTOR, DOMÍNGUEZ,JORGE J, ROBLEDO,SARA M, MUÑOZ,DIANA L, FIGADERE,BRUNO, VELEZ,IVAN D, SÁEZ,JAIRO
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2013
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200014
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