SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
A new Schiff base ligands (H2L¹-H2L³) was synthesized by the condensation reaction of 4-acyl pyrazolones and 2-benzothiazolyl thiosemicarbazide. The ruthenium(II) Schiff base complexes were prepared by the interaction of the ligands with [RuHCl(CO)(EPh3)2(B)] (E=P/As; B=PPh3/AsPh3/py). They were characterized by elemental analysis, IR, UV-vis, ¹H, 13C, and 31P NMR spectral data. The interaction of the complexes with CT-DNA has been investigated by electronic absorption spectroscopy technique and the binding mode of the complexes with CT-DNA has been explored. Furthermore, the DNA cleavage activities of the complexes were performed by agarose gel electrophoresis on CT-DNA.
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| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2013
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100029 |
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