SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS

Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).

Bibliographic Details

Main Authors:	ESPINOZA CATALÁN,LUIS, MADRID VILLEGAS,ALEJANDRO, TABORGA LIBER,LAUTARO, VILLENA GARCÍA,JOAN, CUELLAR FRITIS,MAURICIO, CARRASCO ALTAMIRANO,HÉCTOR
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Química 2010
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016
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