SYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY

The reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,12-olide 3, whose structures reported in this study were established by spectroscopy (¹H-NMR, 13C-NMR, MS and IR) and confirmedthrough ROESY experiments and theoretical studies by molecular mechanics. The in vitro cytotoxicity of these isomeric compounds was less active than leptocarpin, showing the importance of the oxirane ring in the biological activity. Cytotoxic activity was measured in six cancer cell lines

Bibliographic Details

Main Authors:	MARTÍNEZ,ROLANDO, KESTERNICH,VICTOR, CARRACSO,HÉCTOR, ÁLVAREZ-CONTRERAS,CAROLINA, MONTENEGRO,CAROLINA, UGARTE,RICARDO, GUTIÉRREZ,ELENA, MORENO,JOSÉ, GARCÍA,CARLOS, WERNER,ENRIQUE, CÁRCAMOS,JUAN
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Química 2006
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000400003
Tags:	Add Tag No Tags, Be the first to tag this record!