Synthesis and antibacterial activity of cefotaxime metal complexes
Cefotaxime (Hcefotax) interacts with transition metal ions to give [M(cefotax)Cl] complexes (M = Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Cd(II)) which were characterized by physicochemical and spectroscopic methods and a tetrahedral geometry is suggested for their structure. The IR and the ¹H-NMR spectra of the complexes suggest that the cefotaxime behaves as monoanionic tridentate ligand . The complexes have been screened for antibacterial activity against several bacteria, and the results are compared with the activity of cefotaxime
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| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2005
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072005000200001 |
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