Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars

This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive ( 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.

Bibliographic Details

Main Authors:	Oliveira,David Moraes de, Silveira,Márcia Maria Ferreira da, Andrade,Emanuel Sávio de Souza, Sobral,Ana Paula Veras, Martins-Filho,Paulo Ricardo Saquete, Santos,Thiago de Santana, Oliveira,Patrícia Leimig Amorim de
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Anatomía 2011
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037
Tags:	Add Tag No Tags, Be the first to tag this record!