Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms

ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes.

Bibliographic Details

Main Authors:	Nunes,Ivone Freires de Oliveira Costa, Rogero,Marcelo Macedo, Sousa,Joyce Ramalho, Rosa,Érica Patrícia Cunha, Carvalho,Marcos David Figueiredo de, Oliveira,Francisco Erasmo de, Nascimento,Leopoldo Fabrício Marçal do, Cruz,Maria do Socorro Pires e, Carvalho,Cecilia Maria Resende Gonçalves de
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Nutrición, Bromatología y Toxicología 2020
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141
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