Interaction of Copper(II) Dithiocarbamates with Hydrogen Peroxide
The possible reaction of copper(II) dithiocarbamates with SOD-like activity and the ligands themselves with hydrogen peroxide was studied. Three dithiocarbamates (DTC) were selected: morpholyl (MorDTC) and those of L-glutamic acid (GluDTC) and L-proline (ProDTC). DTC salts reacted with H2O2, in a non-catalytic way, to form the corresponding disulfide and water. It was assumed that a sulfidyl radical is formed as intermediate. When these DTC form highly stable complexes with Cu(II), no interaction takes place. In the case of Cu(GluDTC)2(4−) a partial dissociation of the complex provokes the reaction of the liberated ligand with H2O2, but disulfide is not formed, since apparently the intermediate reacts via redox with Cu(II), conducting to the total decomposition of the complex.
| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2000
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0583-76932000000200020 |
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