Structural Characterization and Thermal Properties of the Anti-malarial Drug: Lumefantrine
The anti-malarial lumefantrine was characterized in the solid as well as the solution state. The solid state analysis was carried out by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), DSC, TG-DTG and ATR-IR. The single crystal structure of lumefantrine has been solved. The structure is stabilized via inter- as well as intra-C-H...Cl interactions, intra hydrogen bonding O-H.. .N interactions and C-H.. .O weak interactions. The Hirshfeld surface intermolecular interactions have been studied using the crystal structure. Solution structure analyses have been done by NMR, COSY/NOESY, HSQC and mass spectrometry. The thermal properties were studied by solid-state differential scanning calorimetry and thermogravimetric analysis of the drug under nitrogen as well as in air.
| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
The South African Chemical Institute
2019
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| Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502019000100033 |
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