Synthesis, crystal structure and anti-ischaemic activity of (E)-1-{4-[Bis(4-methoxy-phenyl)methyl]piperazin-1-yl}-3-(4-chlorophenyl)-prop-2-en-1-one

The title compound (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chloro- phenyl)prop-2-en-1-one (C28H29ClN2O3, Mr = 476.98) (5) was synthesized and studied by the single crystal X-ray diffraction method. Its structure was confirmed by ¹H NMR, 13C NMR, HRMS and X-ray single crystal structure determination. Compound 5 crystallized in the monoclinic system, space group P2(1)/c with a = 10.392(2), b = 7.9180(16), c = 30.474(6) Å, β = 97.78(3) °, V = 2484.4(9) ų,Z = 4, Dc = 1.275 g cm-3, F(000) = 1008, μ = 0.186 mm-1,MoKa radiation (λ = 0.71073 Å), R = 0.0692 and wR = 0.1469 for 2046 observed reflections with I 2σ(I). The title compound was screened for the anti-ischaemic activity in vivo. The results showed that compound 5 significantly prolonged the survival time of mice subjected to acute cerebral ischaemia at all doses tested and exhibited potent neuroprotective activity.

Bibliographic Details

Main Authors:	Zhong,Yan, Xu,Zhaoying, Wang,Yao, Xu,Yi, Li,Ping, Wu,Bin
Format:	Digital revista
Language:	English
Published:	The South African Chemical Institute 2014
Online Access:	http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502014000100033
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