Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi

Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi

The known 3,6-dibromoindole (1), 6-bromo-3-chloroindole (2) and 6-bromo-2-oxindole (3) were isolated from the marine ascidian (sea squirt) Distapia skoogi collected from Algoa Bay, South Africa. Standard spectroscopic techniques were used to elucidate the structures of 1-3. All three compounds were found to be moderately cytotoxic to metastatic MDA-MB-231 breast cancer cells.

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Bibliographic Details
Main Authors: Bromley,Candice L., Parker-Nance,Shirley, de la Mare,Jo-Anne, Edkins,Adrienne L., Beukes,Denzil R., Davies-Coleman,Michael T.
Format: Digital revista
Language:English
Published: The South African Chemical Institute 2013
Online Access:http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502013000100015
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http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502013000100015

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