Comparison of tetrahydroisoquinoline (TIQ) thiazole and oxazoline ligands for asymmetric Henry reactions
A series of novel C¹ symmetric thiazole ligands with a tetrahydroisoquinoline (TIQ) backbone were synthesized. Their application in the catalytic asymmetric Henry reaction was investigated with comparison to a corresponding TIQ oxazoline ligand. The Cu(II)-oxazoline complex was more reactive and furnished moderate enantioselectivities up to 61:36 (syn:anti) with 75:25 diastereomeric excess, while the Cu(II)-thiazole complexes had lower selectivity. This is the first example where a direct comparison between an N, N-type thiazole and oxazoline ligands has been studied.
Main Authors: | , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
The South African Chemical Institute
2012
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Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502012000100005 |
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