A simple, rapid and efficient one-pot protocol for the synthesis of 2-substituted benzothiazole derivatives and their antimicrobial screening
A rapid and efficient condensation reaction of 2-aminothiophenol with various fatty acids in solvent-free conditions with or without microwave irradiation was carried out to afford the corresponding 2-substituted benzothiazole derivatives in good to excellent yields. The structures of the new products were established by elemental analyses, IR, ¹H NMR, 13C NMR and mass spectral data. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited good antimicrobial activity.
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| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
The South African Chemical Institute
2008
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| Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502008000100013 |
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