AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 muM and for 7-deacetylazorellanol was 42 mM.
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| Main Authors: | , , , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2001
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000100003 |
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