Vemurafenib and cutaneous adverse events - report of five cases

Abstract Vemurafenib is a selective inhibitor of V600E-mutant BRAF protein used to treat metastatic and unresectable melanoma. Clinical trials have shown increased overall survival and progression-free survival in patients treated with Vemurafenib. However, cutaneous adverse events are common during treatment. We report fi ve cases of metastatic melanoma with BRAF V600E positivity, treated with Vemurafenib and its cutaneous adverse events. Dermatologists and oncologists need to be aware of possible skin changes caused by this medication, which is increasingly employed in melanoma treatment. Monitoring of patients during therapy is important for early treatment of adverse cutaneous cutaneous adverse events, improvement in quality of life and adherence to treatment.

Bibliographic Details

Main Authors:	Silva,Giselle de Barros, Mendes,Adriana Pessoa, Macedo,Mariana Petaccia de, Pinto,Clóvis Antônio Lopes, Gibbons,Ivana Lameiras, Duprat Neto,João Pedreira
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Dermatologia 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700242
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