Non-IgE-mediated food allergies

Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.

Bibliographic Details

Main Authors:	Terblanche,A J, Gray,A C Lang C L, Goddard,E, Karabus,S, Kriel,M, Manjra,A I, Risenga,S M, van der Spuy,D A, Levin,M E
Format:	Digital revista
Language:	English
Published:	South African Medical Association 2015
Online Access:	http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742015000100026
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