Hutchinson's sign as a marker of ocular involvement in HIV-positive patients with herpes zoster ophthalmicus

BACKGROUND: A positive Hutchinson's sign indicates an increased risk of ocular involvement in herpes zoster ophthalmicus (HZO). We examined the sensitivity of Hutchinson's sign as an indicator of ocular involvement in a consecutive series of patients presenting with HZO. METHODS: We conducted a descriptive observational prospective study of patients >18 years old presenting with HZO and consenting to pre- and post-test counselling and HIV and CD4 testing. A full ophthalmological examination focused on the extent of ocular involvement, and the presence of Hutchinson's sign was confirmed by two clinicians. RESULTS: Thirty-three patients were enrolled; 29 were HIV positive, of whom 18 (62%) had not been diagnosed with HIV prior to enrolment. Of the 29 HIV-positive patients, 21 (72%) were Hutchinson's sign positive (HSP), all of whom had intra-ocular involvement (95% confidence interval 88 - 100%). Of the 8 HIV-positive, Hutchinson's sign-negative (HSN) patients, 4 did and 4 did not display intra-ocular involvement. Neither the mean CD4 count nor the average age in the HSP group differed significantly from the HSN group. CONCLUSION: We confirmed that a Hutchinson's sign- and HIVpositive patient with HZO has a very high positive predictive value for intra-ocular involvement. Neither age nor CD4 count had predictive value for ocular involvement. Young adults presenting with HZO should be suspected of having HIV, and HIV-positive patients with HZO but HSN may still have ocular involvement. All patients with HZO should be seen by an ophthalmologist.

Bibliographic Details

Main Authors:	van Dyk,M, Meyer,D
Format:	Digital revista
Language:	English
Published:	South African Medical Association 2010
Online Access:	http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742010000300020
Tags:	Add Tag No Tags, Be the first to tag this record!