Vitamin D levels and their association with oxidative stress and inflammation markers in patients with cystic fibrosis

Abstract Introduction: cystic fibrosis is a disease that causes inflammation, oxidative stress and metabolic changes that lead to nutrient deficiency, such as vitamin D deficiency. On the other hand, it is suggested that vitamin D has anti-inflammatory and antioxidant actions. Objective: to evaluate the prevalence of hypovitaminosis D and the association between serum 25 hydroxyvitamin D levels with markers of oxidative stress and inflammation in patients with cystic fibrosis. Method: a cross-sectional study was carried out with 48 patients with cystic fibrosis including children, adolescents and adults in the northeast region of Brazil. Blood collection was performed for analysis of 25-hydroxyvitamin D, calcium, parathyroid hormone, inflammatory process (C-reactive protein [CRP] and alpha-1-acid glycoprotein-A1 [A1GPA]) and oxidative stress (malondialdehyde (MDA) and total antioxidant capacity [CAOT]). The statistical analysis was performed using the "Statistical Package for the Social Sciences", adopting a significance level of p < 0.05. Results: vitamin D insufficiency/deficiency was found in 64.6 % of patients. After multiple linear regression analysis, MDA showed an inverse association with blood values of 25-hydroxyvitamin D (p < 0.05) conditioned by the presence of inflammatory process markers. When only oxidative stress was evaluated, this association disappeared. Conclusion: in conclusion, there was a high prevalence of hypovitaminosis D, with 25(OH)D levels associated with greater oxidative stress when combined with inflammatory markers. Improved vitamin D levels may be an alternative to reduce the damage caused by excess oxidative stress and inflammation in CF patients.

Bibliographic Details

Main Authors:	Queiroz,Dayanna Joyce Marques, Silva,Alexandre Sérgio, Júnior,Celso Costa da Silva, Persuh,Darlene Camati, Diniz,Alcides da Silva, Lima,Rafaela Lira Formiga Cavalcanti de, Paiva,Maria Paula de, Cartaxo,Constantino Giovanni Braga, Bezerra,Patrícia Gomes de Matos, Ribeiro,Mateus Duarte, Gonçalves,Maria da Conceição Rodrigues
Format:	Digital revista
Language:	English
Published:	Grupo Arán 2023
Online Access:	https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112023000300007
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