Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety

SUMMARY Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.

Bibliographic Details

Main Authors:	Silva Filho,Agnaldo Lopes da, Carvalho,Gabriella Martins, Sena,Larissa Cristelli de, Gomes,Lívia Passini Guimarães, Valério,Marcos Flávio Habib, Martins,Raíssa Isabelle Leão, Cândido,Eduardo Batista
Format:	Digital revista
Language:	English
Published:	Associação Médica Brasileira 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801134
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