α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
Abstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.
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| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Associação Brasileira de Polímeros
2016
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304 |
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