Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays

ABSTRACT: The aqueous extract of Aristolochia triangularis leaves showed activity against Artemia salina larvae, with an LD50 of 370.6 µg/mL. In experiments with Allium cepa seeds, the extract caused a 51.26% reduction in the germination index, inhibited mean root growth, and was cytotoxic at concentrations of 668 and 2,000 µg/mL. Its antioxidant activity was additionally assessed in this research and the ferric reducing antioxidant power value was found to be 391.2 µM/g. Such health-beneficial property can be attributed partly to the total phenolic content, spectrophotometrically determined as 52.67 mg/g. The occurrence of cytotoxicity suggested caution when consuming teas from A. triangularis leaves for medicinal purposes, and equally reveals the need for further studies to investigate their adverse effects.

Bibliographic Details

Main Authors:	Silva,José Darlan Alves da, Nogueira,Cláudio Rodrigo, Vieira,Maria do Carmo, Heredia-Vieira,Silvia Cristina, Barufatti,Alexeia, Crispim,Bruno do Amaral, Francisco,Luiza Flávia Veiga, Viana,Lucilene Finoto, Cardoso,Claudia Andrea Lima
Format:	Digital revista
Language:	English
Published:	Universidade Federal de Santa Maria 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800753
Tags:	Add Tag No Tags, Be the first to tag this record!