Extranodal Nasal NK/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression

Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with Epstein-Barr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results.

Bibliographic Details

Main Authors:	Pontes,Helder Antonio Rebelo, Pontes,Flavia Sirotheau Correa, Silva,Brunno Santos de Freitas, Fonseca,Felipe Paiva, Andrade,Bruno Augusto Benevenuto de, Rizo,Victor Hugo Toral, Romanach,Mario Jose, Leon,Jorge Esquiche, Almeida,Oslei Paes de
Format:	Digital revista
Language:	English
Published:	Fundação Odontológica de Ribeirão Preto 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402013000300284
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