Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders

This study describes a single step, high yield and purity, ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 × 107 M−1 s−1) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC50) = 23.07 µM) but not with superoxide anion radical or hydrogen peroxide without any cytotoxicity. These results show that this synthetically simple selenide reacts in a very efficient and specific way with the harmful pro-oxidant HOCl being a promising compound to be applied in oxidative inflammatory-related conditions.

Bibliographic Details

Main Authors:	Pinatto-Botelho,Marcos F., Silva,Railmara P. da, Archilha,Marcos V. L. R., Giroldo,Lilian, Kuznetsov,Aleksey E., Meotti,Flávia C., Santos,Alcindo A. dos
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000601239
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