Photodegradation of Fluoxetine Applying Different Photolytic Reactors: Evaluation of the Process Efficiency and Mechanism

Photolytic degradation of fluoxetine (FLX), a medicine commonly known as Prozac®, was evaluated by using different photochemical processes. The ultraviolet/microwave (UV/MW) process showed higher efficiency in all the aspects evaluated in this study. The energy consumption was equivalent to 1.94 × 10-4 kW h mg-1 L (UV/MW), while in the UV process the value was 1.20 × 10-2 kW h mg-1 L. The degradation kinetics were applied to the FLX, with rate constant (k) = 0.15 ± 0.01 min-1 and linear correlation coefficient (R2) = 0.980 for UV, and k = 6.15 ± 0.08 min-1 and R2 = 0.998 for UV/MW. The FLX degradation of 99.16% (UV/MW 5 min) and 98.90% (UV 120 min) were observed, evidencing higher efficiency for the first process. The monitoring of transformation products (TPs) through chromatographic analysis enabled the identification of 9 TPs, proving that for the UV/MW process, the hydroxylated structures are verified in high quantity.

Bibliographic Details

Main Authors:	Moreira,Ailton J., Borges,Aline C., Sousa,Bianca B. de, Mendonça,Vagner R. de, Freschi,Carolina D., Freschi,Gian P. G.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501010
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