New Antiproliferative Polyunsaturated Epoxy-Heneicosane Derivatives Isolated from the Brown Alga Lobophora variegata

Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted to antiproliferative assays against the human colon cancer cell line HCT-116, human metastatic prostate cancer PC-3M, murine metastatic melanoma B16-F10 and murine fibroblast cell line L929 and also tested as antibacterial. Both 3,4-epoxy lobophorene A and 3,4-epoxy lobophorene B depicted moderate antiproliferative effect against cell lines. None of them showed antibacterial activity.

Bibliographic Details

Main Authors:	Ávila,Fábio N., Pinto,Francisco C. L., Carneiro,Pedro B. M., Ferreira,Kayanny Q., Wilke,Diego V., Nogueira,Nádia A. P., Silveira,Edilberto R., Pessoa,Otília Deusdênia L.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000200406
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