Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®

Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®

Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.

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Bibliographic Details
Main Authors: Dutra,Lillian M. U., Cavalcante,Igor M., Brito,Débora H. A. de, Vieira,Ícaro G. P., Trevisan,Maria T. S., Ribeiro,Maria E. N. P., Yeates,Stephen G., Ricardo,Nágila M. P. S.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701341
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