Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis of cis-4-Amido-N-yl-2-methyl-tetrahydroquinolines

Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis of cis-4-Amido-N-yl-2-methyl-tetrahydroquinolines

The ball-milling process of ABB' Povarov reaction through mechano-chemical activation with phosphomolybdic acid (PMA) as heteropolyacid (HPA) catalyst, was first time explored. The developed high speed vibratory ball milling (HSVBM) green method offers simple and efficient diastereoselective synthesis of cis-2,4-disubstituted tetrahydroquinolines in good to excellent yields (56-76%).

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Bibliographic Details
Main Authors: Kouznetsov,Vladimir V., Merchán-Arenas,Diego R., Martínez-Bonilla,Carlos A., Macías,Mario A., Roussel,Pascal, Gauthier,Gilles H.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202246
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