Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate

A series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies. The newly synthesized compounds were evaluated as new drug candidates in in silico study and for their antifungal activity against several strains of Candida albicans. In silico study indicates that no compound has potential to be a new drug while four compounds showed medium to strong activity with minimum inhibitory concentration (MIC) range of 256-1024 µg mL-1.

Bibliographic Details

Main Authors:	Peixoto,Isabelle N., Souza,Helivaldo D. S., Lira,Bruno F., Silva,Daniele F., Lima,Edeltrudes O., Barbosa-Filho,José M., Athayde-Filho,Petrônio F. de
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001001807
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