Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.

One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM.

Bibliographic Details

Main Authors:	Carvalho,Kaline R., Silva,Alison B., Torres,Maria Conceição M., Pinto,Francisco Chagas L., Guimarães,Larissa A., Rocha,Danilo D., Silveira,Edilberto R., Costa-Lotufo,Letícia V., Braz‑Filho,Raimundo, Pessoa,Otília Deusdênia. L.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976
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