On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis

On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis

Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values < 6.25 µg mL-1. These substances are promising antimycobacterial prototypes.

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Bibliographic Details
Main Authors: Jardim,Guilherme A. M., Cruz,Eduardo H. G., Valença,Wagner O., Resende,Jarbas M., Rodrigues,Bernardo L., Ramos,Daniela F., Oliveira,Ronaldo N., Silva,Pedro E. A., Silva Júnior,Eufrânio N. da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013
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