Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase

Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the enzyme-inhibitor interactions. The significant inhibitory activity of gallic acid on ARG can be a clue to understand the immune response previously observed on L. donovani, since ARG activity is associated with the decrease of the levels of NO in Leishmania infection.

Bibliographic Details

Main Authors:	Sousa,Lorena R. F. de, Ramalho,Suelem D., Fernandes,João B., Silva,Maria Fátima das G. F. da, Iemma,Mônica R. da C., Corrêa,Caroindes J., Souza,Dulce H. F. de, Lima,Maria I. S., Vieira,Paulo C.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2014
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000008
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