Synthesis and in vitro evaluation of new benzenesulfonamides as antileishmanial agents

Synthesis and in vitro evaluation of new benzenesulfonamides as antileishmanial agents

This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

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Bibliographic Details
Main Authors: Borges,Julio C., Carvalho,Adriana V., Bernardino,Alice M. R., Oliveira,César D., Pinheiro,Luiz C. S., Marra,Roberta K. F., Castro,Helena C., Wardell,Solange M. S. V., Wardell,James L., Amaral,Veronica F., Canto-Cavalheiro,Marilene M., Leon,Leonor L., Genestra,Marcelo
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000500023
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