Novel bioactive dibenzocyclooctadiene lignans from Schisandra neglecta

Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines.

Bibliographic Details

Main Authors:	Gao,Xue-Mei, Niu,De-Yun, Meng,Chun-Yang, Yao,Fu-Quan, Zhou,Bin, Wang,Rui-Rui, Yang,Liu-Meng, Zheng,Yong-Tang, Hu,Qiu-Fen, Sun,Han-Dong, Xiao,Wei-Lie
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013001200017
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