Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm

Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm

The continuity of the phytochemical study of crude extracts of P. prunifolia's roots and branches led to the isolation of five indole-β-carboline alkaloids. Among them, the 10-hydroxy-iso-deppeaninol and N-oxide-10-hydroxy-antirhine derivatives are described here for the first time. The structures were achieved through 1D and 2D NMR, IR and HRMS analyses. The branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide showed selective activity against L. amazonensis, with IC50 values of 16.0 and 40.7 µg per mL, respectively.

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Bibliographic Details
Main Authors: Lucilia,Kato, Oliveira,Cecília M. A. de, Faria,Emiret O., Ribeiro,Laryssa C., Carvalho,Brenda G., Silva,Cleuza C. da, Schuquel,Ivânia T. A., Santin,Silvana M. O., Nakamura,Celso V., Britta,Elisandra A., Miranda,Nathielle, Iglesias,Amadeu H., Delprete,Piero G.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200024
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