Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives

Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives

Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.

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Bibliographic Details
Main Authors: Santos,Maurício S. dos, Gomes,Adriana O, Bernardino,Alice M. R, Souza,Marcos C. de, Khan,Misbahul A, Brito,Monique A. de, Castro,Helena C, Abreu,Paula A, Rodrigues,Carlos R, Léo,Rosa M. M. de, Leon,Leonor L, Canto-Cavalheiro,Marilene M
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200022
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