A highly efficient and general method for the preparation of (Z)-allylic bromides derived from Morita-Baylis-Hillman adducts
Representative (Z)-2-(bromomethyl)-2-alkenoates were easily prepared in high yield by treating α-methylene-β-hydroxyesters (Morita-Baylis-Hillman adducts) with LiBr/H2SO4 in acetonitrile at room temperature. Besides the tolerance to many diverse functional groups, this new methodology employs inexpensive reagents and avoids the use of HBr.
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| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2009
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300023 |
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