A solvent-free synthesis of beta-enamino trihalomethyl ketones
An efficient green procedure to prepare a series of twenty-six 4-amino-1,1,1-trihalo-3-alken-2-ones [CX3C(O)CH=C(R¹)NR² R³, where X = F, Cl, R¹ = H, Me, and R²/R³ = H/Ph, H/4-F-Ph, H/Bn, H/(CH2)2OH, Me/Ph, Me/Bu, Et/Et, -(CH2)4-] from the solvent-free reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with primary and secondary amines at room temperature for five minutes is reported (yields of 73-99%).
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Main Authors: | , , , , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Química
2007
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000800006 |
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Summary: | An efficient green procedure to prepare a series of twenty-six 4-amino-1,1,1-trihalo-3-alken-2-ones [CX3C(O)CH=C(R¹)NR² R³, where X = F, Cl, R¹ = H, Me, and R²/R³ = H/Ph, H/4-F-Ph, H/Bn, H/(CH2)2OH, Me/Ph, Me/Bu, Et/Et, -(CH2)4-] from the solvent-free reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with primary and secondary amines at room temperature for five minutes is reported (yields of 73-99%). |
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