A solvent-free synthesis of beta-enamino trihalomethyl ketones

A solvent-free synthesis of beta-enamino trihalomethyl ketones

An efficient green procedure to prepare a series of twenty-six 4-amino-1,1,1-trihalo-3-alken-2-ones [CX3C(O)CH=C(R¹)NR² R³, where X = F, Cl, R¹ = H, Me, and R²/R³ = H/Ph, H/4-F-Ph, H/Bn, H/(CH2)2OH, Me/Ph, Me/Bu, Et/Et, -(CH2)4-] from the solvent-free reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with primary and secondary amines at room temperature for five minutes is reported (yields of 73-99%).

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Bibliographic Details
Main Authors: Martins,Marcos A. P., Peres,Rodrigo L., Fiss,Gabriela F., Dimer,Frantiescoli A., Mayer,Rodrigo, Frizzo,Clarissa P., Marzari,Mara R. B., Zanatta,Nilo, Bonacorso,Helio G.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000800006
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