Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2006
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500015 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|