Pyrrolizidine alkaloids from Heliotropium indicum

Helindicine (1), a new pyrrolizidine alkaloid with unusual structural features, together with the known lycopsamine (2), were isolated from the roots of Heliotropium indicum (Boraginaceae). The structures were established by a combination of 1D and 2D NMR methods (COSY, HMQC, HMBC, and NOESY) and HREIMS. This is the first report of a lactone pyrrolizidine alkaloid in the genus Heliotropium. Compounds 1 and 2 were assayed for antioxidant activity and showed moderate activity.

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Bibliographic Details
Main Authors: Souza,João Sammy N., Machado,Luciana L., Pessoa,Otília D. L., Braz-Filho,Raimundo, Overk,Cassia R., Yao,Ping, Cordell,Geoffrey A., Lemos,Telma L. G.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2005
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800019
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