Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: anti-inflammatory and anticholinesterasic activities

Combretum leprosum Mart. & Eicher (Combretaceae) leaves and roots ethanolic extracts were investigated by HRGC-MS and showed mono- and oligosaccharides, fatty acids and triterpenes as major compounds after derivatization with BSTFA/ TMCS. Arjunolic acid (1) was quantified on dried roots ethanolic extract (65%) by external standard. Anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities were observed for roots ethanolic extract of C. leprosum and arjunolic acid, suggesting both as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.

Bibliographic Details

Main Authors:	Facundo,Valdir A., Rios,Katiúscia A., Medeiros,Ciléia M., Militão,Júlio S. L. T., Miranda,Ana Luisa P., Epifanio,Rosângela de A., Carvalho,Meriane P., Andrade,Aline T., Pinto,Angelo C., Rezende,Claudia M.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2005
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800002
Tags:	Add Tag No Tags, Be the first to tag this record!