Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus

A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-inflammatory activity by the use of the mouse pleurisy model induced by lipopolysaccharide (LPS, 12.5 ng/cavity). Both the mixture and remirol showed a dose-dependent (100 and 200 mg kg-1 p. o.) capacity to inhibit neutrophil and eosinophil accumulation in the mouse pleural cavity. In contrast, no anti-inflammatory effect was observed for iso-evodionol.

Bibliographic Details

Main Authors:	Siani,Antonio C., Silva,Ana M. P., Nakamura,Marcos J., De Carvalho,Márcia V., Henriques,Maria G. M. O., Ramos,Mônica F. S., Kaiser,Carlos R.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2001
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300006
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