Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?

ABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.

Bibliographic Details

Main Authors:	Rabelo,Nícollas Nunes, Pipek,Leonardo Zumerkorn, Nascimento,Rafaela Farias Vidigal, Telles,João Paulo Mota, Barbato,Natalia Camargo, Coelho,Antônio Carlos Samaia da Silva, Barbosa,Guilherme Bitencourt, Yoshikawa,Marcia Harumy, Teixeira,Manoel Jacobsen, Figueiredo,Eberval Gadelha
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000100206
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