Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.

Bibliographic Details

Main Authors:	Menezes,Honório Sampaio, Bueno,Bárbara Beatriz Moreira, Ciulla,Leandro, Schuh,Alexandre, Luz,Fernanda de Freitas, Alves,Rafael José Vargas, Abegg,Milena Pacheco, Cirino,Sílvia Letícia Merceo Bacchi
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000500010
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