Behavior of cholinesterase and liver mitochondrial function in dogs submitted to normothermic ischemia and reperfusion

PURPOSE: The plasmatic activity of the cholinesterase (CHE) and the liver mitochondrial function, expressed by the ratio of respiratory control (RCR), were studied during normothermic ischemia. METHODS: Sixteen adult mongrels, eight females and eight males were submitted to ischemia by clamping of the hepatic artery, portal vein and infrahepatic inferior vena cava, infra-hepatic, for two h, follwed by reperfusion for 1 h. The CHE and the mitochondrial function were evaluated at 60 and 120 min. of ischemia and at 15 and 60 minutes of reperfusion. RESULTS: The CHE decreased, significantly, during ischemia and in reperfusion. The RCR was decreased at 120 min. of ischemia, returning to the initial values on reperfusion. CONCLUSION: In this study, the CHE was a sensitive indicator of ischemic injury , suggesting irreversibility of ischemia injury. The RCR, by other side, showed a greater sensibility than the CHE in detection sense, during the studied period, the reversibility of the hepatic ischemic injury.

Bibliographic Details

Main Authors:	Fernandes,Luis Pinto, Sankarankutty,Ajith Kumar, Pacheco,Eduardo Garcia, Centurion,Sérgio, Jordani,Maria Cecília, Castro e Silva Jr,Orlando de
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2003
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502003001200014
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