Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

Bibliographic Details

Main Authors:	Tauchen,Jan, Bortl,Ludvik, Huml,Lukas, Miksatkova,Petra, Doskocil,Ivo, Marsik,Petr, Villegas,Pablo Pedro Panduro, Flores,Ymber Bendezu, Damme,Patrick Van, Lojka,Bohdan, Havlik,Jaroslav, Lapcik,Oldrich, Kokoska,Ladislav
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Farmacognosia 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600728
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