Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis

Gaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 µg/mL. FC was further fractionated affording isolated compound 2β, 3β-dihydroxy-urs-12-ene-28-oic acid , identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines.

Bibliographic Details

Main Authors:	Rodrigues,Rodney Alexandre Ferreira, Carvalho,João Ernesto de, Sousa,Ilza Maria de Oliveira, Antônio,Marcia Aparecida, Pizão,Paulo Eduardo, Kohn,Luciana Konecny, Amaral,Maria do Carmo Estanislau do, Bittrich,Volker, Foglio,Mary Ann
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Farmacognosia 2011
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000400010
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