Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results

Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.

Bibliographic Details

Main Authors:	Braga,Cynthia, Albuquerque,Maria de Fátima Pessoa Militão de, Cordeiro,Marli Tenório, Castanha,Priscila M. S., Ramesh,Anita, Alexander,Neal, Mello,Maria Júlia G. de, Marques Jr,Ernesto T. A., Martelli,Celina M. Turchi
Format:	Digital revista
Language:	English
Published:	Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601
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