Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis

The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.

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Main Authors: Zhang,X., Song,Y., Song,N., Zhang,L., Wang,Y., Li,D., Wang,Z., Qu,X., Liu,Y.
Format: Digital revista
Language:English
Published: Associação Brasileira de Divulgação Científica 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602
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spelling oai:scielo:S0100-879X20180003006022019-03-19Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysisZhang,X.Song,Y.Song,N.Zhang,L.Wang,Y.Li,D.Wang,Z.Qu,X.Liu,Y. RANKL RANK Gastric cancer IHC overall survival The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.51 n.3 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602en10.1590/1414-431x20176265
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author Zhang,X.
Song,Y.
Song,N.
Zhang,L.
Wang,Y.
Li,D.
Wang,Z.
Qu,X.
Liu,Y.
spellingShingle Zhang,X.
Song,Y.
Song,N.
Zhang,L.
Wang,Y.
Li,D.
Wang,Z.
Qu,X.
Liu,Y.
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
author_facet Zhang,X.
Song,Y.
Song,N.
Zhang,L.
Wang,Y.
Li,D.
Wang,Z.
Qu,X.
Liu,Y.
author_sort Zhang,X.
title Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
title_short Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
title_full Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
title_fullStr Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
title_full_unstemmed Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
title_sort rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
description The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.
publisher Associação Brasileira de Divulgação Científica
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602
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