Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.
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Associação Brasileira de Divulgação Científica
2018
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oai:scielo:S0100-879X20180003006022019-03-19Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysisZhang,X.Song,Y.Song,N.Zhang,L.Wang,Y.Li,D.Wang,Z.Qu,X.Liu,Y. RANKL RANK Gastric cancer IHC overall survival The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.51 n.3 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602en10.1590/1414-431x20176265 |
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Zhang,X. Song,Y. Song,N. Zhang,L. Wang,Y. Li,D. Wang,Z. Qu,X. Liu,Y. |
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Zhang,X. Song,Y. Song,N. Zhang,L. Wang,Y. Li,D. Wang,Z. Qu,X. Liu,Y. Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
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Zhang,X. Song,Y. Song,N. Zhang,L. Wang,Y. Li,D. Wang,Z. Qu,X. Liu,Y. |
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Zhang,X. |
title |
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
title_short |
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
title_full |
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
title_fullStr |
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
title_full_unstemmed |
Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
title_sort |
rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis |
description |
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer. |
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Associação Brasileira de Divulgação Científica |
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2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602 |
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