Role of Notch signaling in the mammalian heart
Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and optimize myocardial injury repair.
| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2014
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000100001 |
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